When you know that you've been taken.
Nothing left to do
When you're begging for a crumb
Nothing left to do
When you've got to go on waiting
Waiting for the miracle to come
— Leonard Cohen, "Waiting for the Miracle"
Dad and I had a conference call with the genomics analysis team yesterday to discuss the Whole Genome Sequencing results. The fundamental takeaway is that with one minor exception, we didn't discover anything new. There were no miracles lurking in my DNA. Their report recommended Regorafenib, which is the next drug my medical oncologist wants to put me on in any case. They did identify several studies I might be eligible for, but the consensus on the call was to pursue the Regorafenib first.
The minor exception is that it's unclear if I've experienced further KRAS mutation in my tumor since I was originally classed as KRAS wild type. The Whole Genome Sequencing seemed to indicate that I was not wild type. We're now trying to run down whether that's test/measurement error, or if my cancer has actually changed. This has some implications for the viability of certain drug treatment options.
The genomics analysis team wants to do an RNA sequencing on me next. We're looking into that now. There's some issues around sample availability, as well as finding properly certified labs to do the work. This is even more pre-clinical the the Whole Genome Sequencing. That definitely qualifies as an even longer shot than the Whole Genome Sequencing did.
So, in the end, Whole Genome Sequencing confirmed what we already knew. I didn't get any wildcard treatment options out of the process. No miracles occurred.
Meanwhile, onward we go.